Description
2,3-difluoro-4-ethoxyphenyl boronic acid is an arylboronic acid built on a benzene core and two lateral fluorines on adjacent ring positions. It serves as the nucleophilic partner in Suzuki-Miyaura cross-coupling, transferring its aryl group to a palladium centre under basic conditions.
Lateral fluorination changes what the coupled product does, not how the coupling runs. Fluorine is small enough to leave molecular shape essentially intact, yet electronegative enough to raise the dipole moment and depress the melting point – which is why fluorinated aryl fragments dominate display-grade liquid crystal formulations.
Key data
- Catalogue code: KC1005
- Category: Boronic Acids
What the substitution pattern does
Two fluorines on adjacent ring positions point their combined dipole across the molecular long axis, not along it. Lateral 2,3-difluorination is the standard route to negative dielectric anisotropy – the property required by vertically aligned display modes, where the field must reorient molecules that start out perpendicular to the substrate.
Typical applications
- formulation of negative-dielectric-anisotropy mixtures for VA display modes
- Suzuki-Miyaura cross-coupling with aryl halides and triflates
- construction of biphenyl and terphenyl cores for liquid crystal mixtures
- late-stage arylation in medicinal and agrochemical discovery routes
- Chan-Lam C-N and C-O couplings under copper catalysis
Ordering
This compound is supplied to order. Pricing depends on quantity and on the specification you need, so it is quoted rather than listed – send an enquiry stating the quantity and any purity or analytical requirement, and you will receive a written quotation.
Handling and documentation
Supplied for laboratory and industrial use by trained personnel only. Not for use as a medicine, food, cosmetic or biocide, and not for administration to humans or animals. Safety documentation is issued with the order; this page is not a source of hazard information.
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